71 activities found

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Investigator Insights: The Therapeutic Potential of Novel PARP Inhibitors in the Clinic for Improved Management of Epithelial Ovarian Cancer

Dr. Bradley Monk discusses the novel PARP inhibitors (PARPi) in clinical development for advanced ovarian cancers and provides the clinical context for their integration into existing treatment paradigms. The biology of ovarian cancers, latest trial data with PARPi, the potential for patient selection, and the ongoing phase III clinical studies are highlighted.
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0.75 CME
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Expert Perspectives: Perspectives in Melanoma XVIII

Drs. John M. Kirkwood and Antoni Ribas summarize the key take-home messages on the latest advances in melanoma research discussed during the Perspectives in Melanoma XVIII Annual Meeting held in Dublin, Ireland. The newest scientific ideas on melanoma genetics and biology, screening and surveillance, BRAF and MEK inhibitor therapy, immunotherapies, and combination strategies are highlighted in a one-on-one dialogue; moreover, global access to novel melanoma drugs and insights on current practice patterns are provided.
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0.5 CME
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Best of the Day: from the American College of Gastroenterology 2014 Annual Scientific Meeting & Postgraduate Course

With multiple new and emerging advancements in the field of inflammatory bowel disease (IBD), and with the volume of patients continuing to increase, healthcare professionals are more challenged than ever to deliver optimal patient care. The Annual Scientific Meeting of the American College of Gastroenterology (ACG) is a leading forum where investigators and healthcare professionals come together, share their knowledge and experience, and learn about the latest advances and new clinical insights in hepatology and gastroenterology, including IBD. In this "Best of the Day" program, Dr. David T. Rubin is joined by Drs. Stephen B. Hanauer, Russell D. Cohen, and Gary R. Lichtenstein to summarize, review, and interpret the clinically significant information presented during the 2014 ACG Annual Scientific Meeting & Postgraduate Course in Philadelphia, Pennsylvania from October 17-22, 2014.
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1 CME
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Best of the Day: from the 2014 European Society of Medical Oncology (ESMO) Congress - Melanoma

This ESMO “Best of the Day” features a one-on-one interview between Dr Axel Grothey and Dr Caroline Robert.. Highlights include: late-breaking updates on the Phase II Co-BRIM trial, an overview of anti-PD-1/PD-L1 antibodies approved and in development, and emerging therapies for BRAF V600E/K mutation-positive melanoma.
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Best of the Day: from the 2014 European Society of Medical Oncology (ESMO) Congress - Breast Cancer

In this "Best of the Day" presentation from ESMO 2014, Dr. Javier Cortes reviews the latest advances, clinical trial updates, and late-breaking news presented during this year's breast cancer sessions. Highlights include final overall survival data from the phase III CLEOPATRA trial for patients with HER2-positive metastatic breast cancer, updates to the phase III IMELDA and TANIA trials, providing an understanding of the benefits of bevacizumab maintenance therapy for patients with HER2-negative metastatic breast cancer, and characterization of breast cancer tumors.
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Best of the Day: from the 2014 European Society of Medical Oncology (ESMO) Congress - Gastrointestinal Cancer

In this "Best of the Day" interview from ESMO 2014, Dr. Axel Grothey is joined by Dr. Florian Lordick to review the latest advances, clinical trial updates, and late-breaking news presented during this year's gastrointestinal malignancies sessions. Discussion highlights include new and emerging therapies for gastric, pancreatic, and colorectal cancers; immunotherapy for GI malignancies; and antiangiogenic agents for advanced GI malignancies.
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Best of the Day: from the 2014 European Society of Medical Oncology (ESMO) Congress - Genitourinary Cancers

In this "Best of the Day" interview from ESMO 2014, Dr. Ramaswamy Govindan is joined by Dr. Cora Sternberg to review the latest advances, clinical trial updates, and late-breaking news presented during this year's genitourinary cancer sessions. Discussion highlights include practice-changing results from the CHAARTED prostate cancer trial; updates on the PREVAIL, COUGAR 302, and AFFIRM trials; and an update on androgen receptor splice variant AR-V7's status as a biomarker to predict resistance to androgen receptor targeting agents.
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Best of the Day: from the 2014 European Society of Medical Oncology (ESMO) Congress - Lung Cancer

In this "Best of the Day" interview from ESMO 2014, Dr. Axel Grothey is joined by Dr. Ramaswamy Govindan to review the latest advances, clinical trial updates, and late-breaking news presented during this year's thoracic oncology sessions. Discussion highlights include new therapies on the horizon for ALK-positive lung cancer, updates on RADIANT and ALCHEMIST thoracic cancer trials, and updates on the molecular characterization of tumors.
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Monograph: The Clinical Application of Therapeutic Drug Monitoring to Optimize Anti-TNFa Therapy in IBD: An Interactive Case-Based Approach

The management of inflammatory bowel disease patients has improved with an increased understanding of the factors that influence the inter-individual variability in efficacy and tolerability of anti-tnf therapies. The field is focusing on improving an understanding of the pharmacokinetic and immunogenicity influences on response heterogeneity. As new clinical findings emerge with the potential to impact patient care, it is essential that healthcare providers remain up-to-date in order to make informed treatment decisions for their patients with IBD. This online monograph will provide an interactive update on therapeutic drug monitoring and provide guidance on algorithmic-based approaches to patients losing response to anti-TNF therapies.
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1 CME
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Expert Perspectives: US Focus on Myeloproliferative Neoplasms and Myelodysplastic Syndromes 2014

Filmed at the US Focus on Myeloproliferative Neoplasms and Myelodysplastic Syndromes 2014 meeting, this video discussion between Drs. Srdan Verstovsek, Ruben A. Mesa, Jason R. Gotlib, and Ramon V. Tiu outlines key learning points and summarizes take home messages from the presented content. This engaging conversational format provides expert perspectives on recent discoveries that have the potential to change the paradigm of how MPNs and MDS are diagnosed and treated, and enhance clinical outcomes and quality of life for patients with MPNs and MDS.
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0.5 CME